Twin Rivers R-X students will be out of class for the rest of the week due to illness.
Superintendent Jeremy Seibert said 109 students and 12 teachers called out sick Wednesday, which prompted the decision.
The district has about 900 students and roughly 70 teachers.
Classes are expected to resume Monday.
The district was also closed for three days in early February, when 90 students and several teachers called in sick. The closure was attributed to illness and flooding.